High Specificity in Protein Recognition by Hydrogen-Bond-Surrogate α-Helices: Selective Inhibition of the p53/MDM2 Complex
Written by Laura K. Henchey on October 18, 2010 – 5:00 am -Split kit: Synthetic helices target chosen protein–protein interactions with high specificity, as assessed by an in vitro split-protein reassembly assay. By using the p53/MDM2 complex as a model system, both the efficacy of the designed ligands and the suitability of the split-protein assay were determined.
Posted in biochem |
