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	<title>Fr Francium</title>
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	<link>http://fr-francium.info</link>
	<description>Just another WordPress weblog</description>
	<pubDate>Wed, 08 Sep 2010 05:00:00 +0000</pubDate>
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	<language>en</language>
			<item>
		<title>Probing Multidrug-Resistance and Protein–Ligand Interactions with Oxatricyclic Designed Ligands in HIV-1 Protease Inhibitors</title>
		<link>http://fr-francium.info/article_1033.html</link>
		<comments>http://fr-francium.info/article_1033.html#comments</comments>
		<pubDate>Wed, 08 Sep 2010 05:00:00 +0000</pubDate>
		<dc:creator>Arun K. Ghosh</dc:creator>
		
		<category><![CDATA[biochem]]></category>

		<category><![CDATA[chemistry]]></category>

		<category><![CDATA[medicine]]></category>

		<guid isPermaLink="false">doi:10.1002/cmdc.201000318</guid>
		<description><![CDATA[A healthier HAART: We report the design, synthesis, biological evaluation, and X-ray crystallographic analysis of a new class of HIV-1 protease inhibitors. Compound 4 proved to be an extremely potent inhibitor toward various multidrug-resistant HIV-1 variants, representing a near 10-fold improvement over darunavir (DRV). Compound 4 also blocked protease dimerization with at least 10-fold greater potency than DRV.]]></description>
			<content:encoded><![CDATA[A healthier HAART: We report the design, synthesis, biological evaluation, and X-ray crystallographic analysis of a new class of HIV-1 protease inhibitors. Compound 4 proved to be an extremely potent inhibitor toward various multidrug-resistant HIV-1 variants, representing a near 10-fold improvement over darunavir (DRV). Compound 4 also blocked protease dimerization with at least 10-fold greater potency than DRV.]]></content:encoded>
			<wfw:commentRss>http://fr-francium.info/article_1033.html/feed</wfw:commentRss>
		</item>
		<item>
		<title>A Triple-Decker Heptadecanuclear (CuII)15(CrIII)2 Complex Assembled from Pentanuclear Metallacrowns</title>
		<link>http://fr-francium.info/article_1011.html</link>
		<comments>http://fr-francium.info/article_1011.html#comments</comments>
		<pubDate>Tue, 07 Sep 2010 05:00:00 +0000</pubDate>
		<dc:creator>Anna V. Pavlishchuk</dc:creator>
		
		<category><![CDATA[biochem]]></category>

		<category><![CDATA[chemistry]]></category>

		<category><![CDATA[inorganic]]></category>

		<guid isPermaLink="false">doi:10.1002/ejic.201000367</guid>
		<description><![CDATA[Reaction of the pentanuclear CuII metallacrown [Cu5(ahpha)4](ClO4)·4H2O (ahpha2– is the dianion of 3-amino-3-(hydroximino)propanehydroxamic acid), with Cr(C2O4)33– led to the formation of a heptadecanuclear complex {[Cu5(ahpha)4]3[Cr(C2O4)3]2·4H2O}·8H2O·1/3(DMF) (1·8H2O·1/3(DMF)). This compound contains three stacked Cu5(ahpha)42+ building blocks, linked by axial bonds between Cu2+ ions of one Cu5 metallacrown and hydroxamate oxygen atoms of the neighboring Cu5 unit. Two Cr(C2O4)33– anions are bonded to the two lateral Cu5(ahpha)42+ cations through axial Cu–O(oxalate) bonds. The formation of 1 may be considered the first example of metallacrown trimerization caused by anion metathesis. The compound contains 10 × 13 Å voids (about 25 % of crystal volume), filled with solvate water molecules. The magnetic properties (χMT vs. T) could be fitted as the superposition of the magnetism of 3χMT(CuII5) and 2χMT(CrIII). Exchange interactions within the CuII5 units were fit in the framework of a model based on the Hamiltonian H(CuII5) = –2J1(S1.S5 + S2.S5 + S3.S5 + S4.S5) –2J2(S1.S2 + S2.S3 + S3.S4 + S4.S1), where S5 represents the central Cu2+ ions' spins and the other spin operators correspond to the peripheral Cu2+ ions. With other possible interactions taken into account using a molecular field approach, the best fit correspondedto J1 = –153(5) cm–1, J2 = –71(2) cm–1 and zJ′ = –0.058(4) cm–1.The heptadecanuclear complex {[Cu5(ahpha)4]3[Cr(C2O4)3]2·14H2O} was obtained starting from a pentanuclear metallacrown. Magnetic properties of the compound are dominated by exchange interactions within the Cu5 building block.
]]></description>
			<content:encoded><![CDATA[Reaction of the pentanuclear CuII metallacrown [Cu5(ahpha)4](ClO4)·4H2O (ahpha2– is the dianion of 3-amino-3-(hydroximino)propanehydroxamic acid), with Cr(C2O4)33– led to the formation of a heptadecanuclear complex {[Cu5(ahpha)4]3[Cr(C2O4)3]2·4H2O}·8H2O·1/3(DMF) (1·8H2O·1/3(DMF)). This compound contains three stacked Cu5(ahpha)42+ building blocks, linked by axial bonds between Cu2+ ions of one Cu5 metallacrown and hydroxamate oxygen atoms of the neighboring Cu5 unit. Two Cr(C2O4)33– anions are bonded to the two lateral Cu5(ahpha)42+ cations through axial Cu–O(oxalate) bonds. The formation of 1 may be considered the first example of metallacrown trimerization caused by anion metathesis. The compound contains 10 × 13 Å voids (about 25 % of crystal volume), filled with solvate water molecules. The magnetic properties (χMT vs. T) could be fitted as the superposition of the magnetism of 3χMT(CuII5) and 2χMT(CrIII). Exchange interactions within the CuII5 units were fit in the framework of a model based on the Hamiltonian H(CuII5) = –2J1(S1.S5 + S2.S5 + S3.S5 + S4.S5) –2J2(S1.S2 + S2.S3 + S3.S4 + S4.S1), where S5 represents the central Cu2+ ions' spins and the other spin operators correspond to the peripheral Cu2+ ions. With other possible interactions taken into account using a molecular field approach, the best fit correspondedto J1 = –153(5) cm–1, J2 = –71(2) cm–1 and zJ′ = –0.058(4) cm–1.The heptadecanuclear complex {[Cu5(ahpha)4]3[Cr(C2O4)3]2·14H2O} was obtained starting from a pentanuclear metallacrown. Magnetic properties of the compound are dominated by exchange interactions within the Cu5 building block.
]]></content:encoded>
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		</item>
		<item>
		<title>Redox and Lewis Acid Reactivity of Unsaturated OsII</title>
		<link>http://fr-francium.info/article_1010.html</link>
		<comments>http://fr-francium.info/article_1010.html#comments</comments>
		<pubDate>Tue, 07 Sep 2010 05:00:00 +0000</pubDate>
		<dc:creator>Nikolay Tsvetkov</dc:creator>
		
		<category><![CDATA[biochem]]></category>

		<category><![CDATA[chemistry]]></category>

		<category><![CDATA[inorganic]]></category>

		<guid isPermaLink="false">doi:10.1002/ejic.201000503</guid>
		<description><![CDATA[A synthesis of [(PNP)OsI] {PNP = (tBu2PCH2SiMe2)2N} permits evaluation of its reactivity, both Lewis acidity and reducing power (i.e., ability to be oxidized). It binds two molecules of PhCN, into trans sites, but only one of ethylene, and, upon binding of one N2, there is heterolytic splitting of one tBu C–H bond to put the proton on amide N and the carbon on Os, leaving divalent metal in [{PN(H)P*}Os(N2)(I)]. Two moles of H2 add, forming [{PN(H)P}OsH(H2)I], via H–H bond heterolysis. Thermolysis of [(PNP)OsI] gives the product of adding a tBu methyl C–H bond across the Os/N bond, and also net dehydrogenation of this intermediate, forming a carbene complex; the released H2 forms [(PNP)OsH2I], and the chemistry of [(PNP)Os] hydridohalides is described. Reaction with O2 occurs with no detectable intermediate, to completely split the O=O bond, and form trans-[(PNP)Os(O)2I], a product of four electron redox change. Attempted two electron oxidation by oxygen atom transfer with pyridine N-oxide or Me3NO or N2O surprisingly effect transposition of N from its silyl substituents onto the metal, and replace N by O, forming a nitride complex of a bis(silyl ether, phosphane) chelate whose oxygen fails to bind to Os. The product is thus four-coordinate, tetrahedral [(POP)Os(N)I], with an Os/N triple bond.Synthesis of [(PNP)OsI] {PNP = (tBu2PCH2SiMe2)2N} shows this paramagnetic 14-valence electron species to rapidly add H2 or ethylene, and to split O2 rapidly at –78 °C to give the hexavalent species illustrated, [(PNP)Os(O)2I]; reaction of [(PNP)OsI] with O-atom transfer reagents gives a product of transposition of amide N with O, [(POP)Os(N)I].
]]></description>
			<content:encoded><![CDATA[A synthesis of [(PNP)OsI] {PNP = (tBu2PCH2SiMe2)2N} permits evaluation of its reactivity, both Lewis acidity and reducing power (i.e., ability to be oxidized). It binds two molecules of PhCN, into trans sites, but only one of ethylene, and, upon binding of one N2, there is heterolytic splitting of one tBu C–H bond to put the proton on amide N and the carbon on Os, leaving divalent metal in [{PN(H)P*}Os(N2)(I)]. Two moles of H2 add, forming [{PN(H)P}OsH(H2)I], via H–H bond heterolysis. Thermolysis of [(PNP)OsI] gives the product of adding a tBu methyl C–H bond across the Os/N bond, and also net dehydrogenation of this intermediate, forming a carbene complex; the released H2 forms [(PNP)OsH2I], and the chemistry of [(PNP)Os] hydridohalides is described. Reaction with O2 occurs with no detectable intermediate, to completely split the O=O bond, and form trans-[(PNP)Os(O)2I], a product of four electron redox change. Attempted two electron oxidation by oxygen atom transfer with pyridine N-oxide or Me3NO or N2O surprisingly effect transposition of N from its silyl substituents onto the metal, and replace N by O, forming a nitride complex of a bis(silyl ether, phosphane) chelate whose oxygen fails to bind to Os. The product is thus four-coordinate, tetrahedral [(POP)Os(N)I], with an Os/N triple bond.Synthesis of [(PNP)OsI] {PNP = (tBu2PCH2SiMe2)2N} shows this paramagnetic 14-valence electron species to rapidly add H2 or ethylene, and to split O2 rapidly at –78 °C to give the hexavalent species illustrated, [(PNP)Os(O)2I]; reaction of [(PNP)OsI] with O-atom transfer reagents gives a product of transposition of amide N with O, [(POP)Os(N)I].
]]></content:encoded>
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		</item>
		<item>
		<title>Orientation of Second-Harmonic-Generation-Active Phenylsulfonyl Chromophores Attached on Layered Lead(II) Phosphonates</title>
		<link>http://fr-francium.info/article_1009.html</link>
		<comments>http://fr-francium.info/article_1009.html#comments</comments>
		<pubDate>Tue, 07 Sep 2010 05:00:00 +0000</pubDate>
		<dc:creator>Zi-Yi Du</dc:creator>
		
		<category><![CDATA[biochem]]></category>

		<category><![CDATA[chemistry]]></category>

		<category><![CDATA[inorganic]]></category>

		<guid isPermaLink="false">doi:10.1002/ejic.201000549</guid>
		<description><![CDATA[The hydrothermal reactions of PbCl2 or PbBr2 with diethyl [(phenylsulfonyl)methyl]phosphonate afforded two lead(II) phosphonates with the formula [Pb3(Ph–SO2–CH2–PO3)2X2(H2O)] [X = Cl (1) and Br (2)]. The two compounds are isostructural and exhibit a lamellar structure in which the phenylsulfonyl chromophores orient unilaterally on the inorganic layer of [Pb3(PO3)2X2(H2O)]. The acentric stacking of such layers results in their crystallization in the noncentrosymmetric Cc space group, and both compounds show second harmonic generation responses comparable to that of KDP (KH2PO4).Two lead(II) phosphonates, [Pb3(Ph–SO2–CH2–PO3)2X2(H2O)] [X = Cl (1) and Br (2)] were synthesized by hydrothermal reactions. The two isostructural compounds exhibit a lamellar structure with phenylsulfonyl chromophores orienting unilaterally on the inorganic layer of [Pb3(PO3)2X2(H2O)]. These compounds show second harmonic generation responses comparable to that of KDP (KH2PO4).
]]></description>
			<content:encoded><![CDATA[The hydrothermal reactions of PbCl2 or PbBr2 with diethyl [(phenylsulfonyl)methyl]phosphonate afforded two lead(II) phosphonates with the formula [Pb3(Ph–SO2–CH2–PO3)2X2(H2O)] [X = Cl (1) and Br (2)]. The two compounds are isostructural and exhibit a lamellar structure in which the phenylsulfonyl chromophores orient unilaterally on the inorganic layer of [Pb3(PO3)2X2(H2O)]. The acentric stacking of such layers results in their crystallization in the noncentrosymmetric Cc space group, and both compounds show second harmonic generation responses comparable to that of KDP (KH2PO4).Two lead(II) phosphonates, [Pb3(Ph–SO2–CH2–PO3)2X2(H2O)] [X = Cl (1) and Br (2)] were synthesized by hydrothermal reactions. The two isostructural compounds exhibit a lamellar structure with phenylsulfonyl chromophores orienting unilaterally on the inorganic layer of [Pb3(PO3)2X2(H2O)]. These compounds show second harmonic generation responses comparable to that of KDP (KH2PO4).
]]></content:encoded>
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		</item>
		<item>
		<title>Synthesis of Two-Dimensional Carbon and Carbon–Metal Nanocomposites Using a Natural Cellular Material as the Carbon Precursor</title>
		<link>http://fr-francium.info/article_1012.html</link>
		<comments>http://fr-francium.info/article_1012.html#comments</comments>
		<pubDate>Mon, 06 Sep 2010 05:00:00 +0000</pubDate>
		<dc:creator>Fengbin Li</dc:creator>
		
		<category><![CDATA[biochem]]></category>

		<category><![CDATA[chemistry]]></category>

		<category><![CDATA[inorganic]]></category>

		<guid isPermaLink="false">doi:10.1002/ejic.201000804</guid>
		<description><![CDATA[Two-dimensional carbon nanostructures, including carbon nanoflakes that are formed from the disassembly of carbon foams and carbon–metal composites, were directly synthesized using the stem pith of the rice-paper plant (SPRP) as the carbon precursor and also the synthesis template. SPRP has a foamlike porous structure. SPRP was pyrolyzed to prepare carbon foam with ultralow apparent density, and this foam was ruptured to produce carbon nanoflakes with a lateral size up to hundreds of micrometers and a thickness of approximately 100 nm. Palladium and platinum were added to the SPRP foams by wet impregnation, and the impregnated foams were subsequently converted into composites of metal nanoparticles and carbon in the form of foams or nanoflakes. The composites were characterized using electron microscopy, energy-dispersive spectroscopy, X-ray diffraction, and Raman spectroscopy. The metal nanoparticles were found to be highly crystalline with diameters in the range of several tens of nanometers (palladium) and several nanometers (platinum), and were uniformly distributed throughout the carbon nanoflakes. The amount of metal in the composite was tunable by changing the impregnation time and the concentration of the impregnation solution.Two-dimensional, flake-shaped carbon and carbon–metal nanocomposites with nanometer-sized thickness and a large lateral size up to hundreds of micrometers were easily synthesized using a naturally existing cellular material, the stem pith of the rice-paper plant, both as the carbon precursor and also the synthesis template.
]]></description>
			<content:encoded><![CDATA[Two-dimensional carbon nanostructures, including carbon nanoflakes that are formed from the disassembly of carbon foams and carbon–metal composites, were directly synthesized using the stem pith of the rice-paper plant (SPRP) as the carbon precursor and also the synthesis template. SPRP has a foamlike porous structure. SPRP was pyrolyzed to prepare carbon foam with ultralow apparent density, and this foam was ruptured to produce carbon nanoflakes with a lateral size up to hundreds of micrometers and a thickness of approximately 100 nm. Palladium and platinum were added to the SPRP foams by wet impregnation, and the impregnated foams were subsequently converted into composites of metal nanoparticles and carbon in the form of foams or nanoflakes. The composites were characterized using electron microscopy, energy-dispersive spectroscopy, X-ray diffraction, and Raman spectroscopy. The metal nanoparticles were found to be highly crystalline with diameters in the range of several tens of nanometers (palladium) and several nanometers (platinum), and were uniformly distributed throughout the carbon nanoflakes. The amount of metal in the composite was tunable by changing the impregnation time and the concentration of the impregnation solution.Two-dimensional, flake-shaped carbon and carbon–metal nanocomposites with nanometer-sized thickness and a large lateral size up to hundreds of micrometers were easily synthesized using a naturally existing cellular material, the stem pith of the rice-paper plant, both as the carbon precursor and also the synthesis template.
]]></content:encoded>
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		</item>
		<item>
		<title>Drugs for Hepatitis C: Unlocking a New Mechanism of Action</title>
		<link>http://fr-francium.info/article_1008.html</link>
		<comments>http://fr-francium.info/article_1008.html#comments</comments>
		<pubDate>Mon, 06 Sep 2010 05:00:00 +0000</pubDate>
		<dc:creator>Thomas W. Bell</dc:creator>
		
		<category><![CDATA[biochem]]></category>

		<category><![CDATA[chemistry]]></category>

		<category><![CDATA[medicine]]></category>

		<guid isPermaLink="false">doi:10.1002/cmdc.201000334</guid>
		<description><![CDATA[The key to unlocking the secret? The nonstructural protein NS5A has no known enzymatic function, but it is essential for hepatitis C virus (HCV) replication and has been proposed to function as a regulator for key replication events. The first clinically validated NS5A inhibitor, developed via chemical genetics screens with HCV replicons, was recently described and this work is highlighted here.]]></description>
			<content:encoded><![CDATA[The key to unlocking the secret? The nonstructural protein NS5A has no known enzymatic function, but it is essential for hepatitis C virus (HCV) replication and has been proposed to function as a regulator for key replication events. The first clinically validated NS5A inhibitor, developed via chemical genetics screens with HCV replicons, was recently described and this work is highlighted here.]]></content:encoded>
			<wfw:commentRss>http://fr-francium.info/article_1008.html/feed</wfw:commentRss>
		</item>
		<item>
		<title>Complementary PCAF–Coenzyme A Mutagenesis: Chemoenzymatic Synthesis of a Novel Enlarged Coenzyme A Analogue and Evaluation of Its Biological Activity</title>
		<link>http://fr-francium.info/article_1007.html</link>
		<comments>http://fr-francium.info/article_1007.html#comments</comments>
		<pubDate>Mon, 06 Sep 2010 05:00:00 +0000</pubDate>
		<dc:creator>Leang Khim</dc:creator>
		
		<category><![CDATA[biochem]]></category>

		<guid isPermaLink="false">doi:10.1002/cbic.201000286</guid>
		<description><![CDATA[Sampling substrate specificity: An enlarged coenzyme A analogue, acetyl-3′′-O-benzyl-CoA, has been synthesised from D-pantethine by using the enzymes DPCK and PPAT. The analogue was evaluated to determine if it is a selective cosubstrate for the histone acetyltransferase PCAF mutant Q581A so as to allow it to be used to identify the non-histone substrates of this enzyme.]]></description>
			<content:encoded><![CDATA[Sampling substrate specificity: An enlarged coenzyme A analogue, acetyl-3′′-O-benzyl-CoA, has been synthesised from D-pantethine by using the enzymes DPCK and PPAT. The analogue was evaluated to determine if it is a selective cosubstrate for the histone acetyltransferase PCAF mutant Q581A so as to allow it to be used to identify the non-histone substrates of this enzyme.]]></content:encoded>
			<wfw:commentRss>http://fr-francium.info/article_1007.html/feed</wfw:commentRss>
		</item>
		<item>
		<title>High Specificity in Protein Recognition by Hydrogen-Bond-Surrogate α-Helices: Selective Inhibition of the p53/MDM2 Complex</title>
		<link>http://fr-francium.info/article_1006.html</link>
		<comments>http://fr-francium.info/article_1006.html#comments</comments>
		<pubDate>Mon, 06 Sep 2010 05:00:00 +0000</pubDate>
		<dc:creator>Laura K. Henchey</dc:creator>
		
		<category><![CDATA[biochem]]></category>

		<guid isPermaLink="false">doi:10.1002/cbic.201000378</guid>
		<description><![CDATA[Split kit: Synthetic helices target chosen protein–protein interactions with high specificity, as assessed by an in vitro split-protein reassembly assay. By using the p53/MDM2 complex as a model system, both the efficacy of the designed ligands and the suitability of the split-protein assay were determined.]]></description>
			<content:encoded><![CDATA[Split kit: Synthetic helices target chosen protein–protein interactions with high specificity, as assessed by an in vitro split-protein reassembly assay. By using the p53/MDM2 complex as a model system, both the efficacy of the designed ligands and the suitability of the split-protein assay were determined.]]></content:encoded>
			<wfw:commentRss>http://fr-francium.info/article_1006.html/feed</wfw:commentRss>
		</item>
		<item>
		<title>Preparation, Crystal Structure, and Properties of Five Metal-Organic Complexes Based on a Triangular Nonplanar Carboxylate Ligand</title>
		<link>http://fr-francium.info/article_1005.html</link>
		<comments>http://fr-francium.info/article_1005.html#comments</comments>
		<pubDate>Fri, 03 Sep 2010 05:00:00 +0000</pubDate>
		<dc:creator>Haiyan He</dc:creator>
		
		<category><![CDATA[biochem]]></category>

		<category><![CDATA[chemistry]]></category>

		<category><![CDATA[inorganic]]></category>

		<guid isPermaLink="false">doi:10.1002/ejic.201000364</guid>
		<description><![CDATA[A nonplanar triangular carboxylate ligand has been synthesized and applied to assemble metal-organic frameworksunder hydro- or solvothermal conditions. Five new metal-organic complexes, [H2N(CH3)2]2[Cd(HTMBTC)2]·2H2O·dmf (1), [Cu3(TMBTC)2(2,2′-bpy)2]·H2O (2), [Zn3(TMBTC)2(H2O)2]·H2O (3), [Cd3(TMBTC)2(H2O)4]·4H2O (4), and [Cu3(TMBTC)2](5), (dmf = dimethylformamide; TMBTC = 2,4,6-trimethylbenzene-1,3,5-tricarboxylic acid; bpy = bipyridine) were crystallized; they possess four different structural types. In 1, the nonplanar carboxylate ligand connects the cadmium ion to give rise to a 2D (4,4) topological layer that contains two vertical left- and right-handed helical chains. In 2, the carboxylate ligands first link the copper ions to generate a 1D tubular unit, which can be considered the basic building block. The 1D tubular units are further connected by the ligand to form a 2D layer structure. Complexes 3 and 4 have similar structural types. The zinc and cadmium ions are connected by the ligand to form a bilayer framework that contains double (6,3) topological nets. Different from complexes 1–4, complex 5 has a 3D framework. The copper ions are first connected by the ligand to generate a bilayer structure that contains double (6,3) nets, which are further connected by sharing the copper ion to form the final 3D framework. Photoluminescence measurements of 1, 3, and 4 in the solid state at room temperature show that all three coordination networks exhibit similar, strong luminescence, which can be assigned to an intraligand π → π* transition.Five metal-organic complexes with four topological structures have been synthesized and characterized based on a nonplanar triangular carboxylate ligand.
]]></description>
			<content:encoded><![CDATA[A nonplanar triangular carboxylate ligand has been synthesized and applied to assemble metal-organic frameworksunder hydro- or solvothermal conditions. Five new metal-organic complexes, [H2N(CH3)2]2[Cd(HTMBTC)2]·2H2O·dmf (1), [Cu3(TMBTC)2(2,2′-bpy)2]·H2O (2), [Zn3(TMBTC)2(H2O)2]·H2O (3), [Cd3(TMBTC)2(H2O)4]·4H2O (4), and [Cu3(TMBTC)2](5), (dmf = dimethylformamide; TMBTC = 2,4,6-trimethylbenzene-1,3,5-tricarboxylic acid; bpy = bipyridine) were crystallized; they possess four different structural types. In 1, the nonplanar carboxylate ligand connects the cadmium ion to give rise to a 2D (4,4) topological layer that contains two vertical left- and right-handed helical chains. In 2, the carboxylate ligands first link the copper ions to generate a 1D tubular unit, which can be considered the basic building block. The 1D tubular units are further connected by the ligand to form a 2D layer structure. Complexes 3 and 4 have similar structural types. The zinc and cadmium ions are connected by the ligand to form a bilayer framework that contains double (6,3) topological nets. Different from complexes 1–4, complex 5 has a 3D framework. The copper ions are first connected by the ligand to generate a bilayer structure that contains double (6,3) nets, which are further connected by sharing the copper ion to form the final 3D framework. Photoluminescence measurements of 1, 3, and 4 in the solid state at room temperature show that all three coordination networks exhibit similar, strong luminescence, which can be assigned to an intraligand π → π* transition.Five metal-organic complexes with four topological structures have been synthesized and characterized based on a nonplanar triangular carboxylate ligand.
]]></content:encoded>
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		</item>
		<item>
		<title>Planar Chiral P,O-Compounds Derived from Ferrocenyl Aryl Ethers</title>
		<link>http://fr-francium.info/article_1004.html</link>
		<comments>http://fr-francium.info/article_1004.html#comments</comments>
		<pubDate>Fri, 03 Sep 2010 05:00:00 +0000</pubDate>
		<dc:creator>Dieter Schaarschmidt</dc:creator>
		
		<category><![CDATA[biochem]]></category>

		<category><![CDATA[chemistry]]></category>

		<category><![CDATA[inorganic]]></category>

		<guid isPermaLink="false">doi:10.1002/ejic.201000722</guid>
		<description><![CDATA[The ortho-directed lithiation of FcOC6H4-4-tBu (1) [Fc = (η5-C5H4)(η5-C5H5)Fe] with nBuLi/tmeda is reported (tmeda = tetramethylethylenediamine). In this reaction, multimetalation occurs to yield novel 1,2-functionalized P,O-derivatives that contain up to four phosphanyl moieties as determined by NMR spectroscopic studies and single-crystal X-ray diffraction analysis. Thus available planar chiral P,O-ferrocenes can successfully be applied in the palladium-catalyzed Suzuki coupling of diverse aryl halides and aryl boronic acids. The aforementioned systems allow the activation of carbon–chlorine bonds in an efficient way and tolerate catalyst loadings as low as 10 ppm. Noteworthy is their remarkable ability to economically generate hindered biaryls under mild reaction conditions.Planar chiral P,O-ferrocenes are excellent ligands in the palladium-mediated C–C coupling of aryl halides and aryl boronic acids. They allow either the conversion ofunreactive substrates or reactions to be performed at low catalyst levels. Moreover, multiply ortho-substituted biaryls are accessible under mild conditions.
]]></description>
			<content:encoded><![CDATA[The ortho-directed lithiation of FcOC6H4-4-tBu (1) [Fc = (η5-C5H4)(η5-C5H5)Fe] with nBuLi/tmeda is reported (tmeda = tetramethylethylenediamine). In this reaction, multimetalation occurs to yield novel 1,2-functionalized P,O-derivatives that contain up to four phosphanyl moieties as determined by NMR spectroscopic studies and single-crystal X-ray diffraction analysis. Thus available planar chiral P,O-ferrocenes can successfully be applied in the palladium-catalyzed Suzuki coupling of diverse aryl halides and aryl boronic acids. The aforementioned systems allow the activation of carbon–chlorine bonds in an efficient way and tolerate catalyst loadings as low as 10 ppm. Noteworthy is their remarkable ability to economically generate hindered biaryls under mild reaction conditions.Planar chiral P,O-ferrocenes are excellent ligands in the palladium-mediated C–C coupling of aryl halides and aryl boronic acids. They allow either the conversion ofunreactive substrates or reactions to be performed at low catalyst levels. Moreover, multiply ortho-substituted biaryls are accessible under mild conditions.
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